Association between the G-protein β3 subunit C825T polymorphism with essential hypertension: a meta-analysis in Han Chinese population
نویسندگان
چکیده
منابع مشابه
Association between polymorphism of the G-protein β3 subunit C825T and essential hypertension: an updated meta-analysis involving 36,802 subjects.
PURPOSE The G-protein β3-subunit gene C825T polymorphism (GNB3-C825T) has been reported to be associated with essential hypertension (EH), but results from previous studies are conflicting. The present study aimed at investigating the association between this polymorphism and risk of EH using a meta-analysis on the published studies. MATERIALS AND METHODS PubMed, Embase, CBM (China Biological...
متن کاملThe C825T Polymorphism of the G-Protein β3 Subunit Gene and Its Association with Hypertension and Stroke: An Updated Meta-Analysis
OBJECTIVE Several epidemiological studies have evaluated the association between the GNB3 C825T polymorphism and hypertension or stroke. The results of these studies were inconsistent; therefore, we performed a meta-analysis to clarify these discrepancies. METHODS We systematically searched the PubMed, Embase, Web of Science, CNKI, and CBM databases, and manually searched reference lists of r...
متن کاملG protein beta 3 subunit gene variants and essential hypertension in the northern Chinese Han population.
Recently a novel C825T polymorphism in the G protein beta3 subunit gene was identified that showed an association with hypertension in a German population; the results of studies in other populations have been inconsistent. To examine the contribution of GNB3 polymorphisms to the development of hypertension in the northern Chinese Han population, we conducted a case-control study consisting of ...
متن کاملThe C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Depression: A Meta-Analysis
BACKGROUND TheG-protein β3 gene (GNβ3) has been implicated in psychiatric illness through its effects upon intracellular transduction of several neurotransmitter receptors. Multiple studies have investigated the relationship of the C825T polymorphism of the GNβ3 gene (GNβ3 C825T) to depression and antidepressant response. However, the relationship between GNβ3 C825T and depression remains incon...
متن کاملPrediction of the Risk for Essential Hypertension among Carriers of C825T Genetic Polymorphism of G Protein β3 (GNB3) Gene
BACKGROUND The guanine nucleotide-binding protein beta polypeptide 3 (GNB3) 825T allele encodes a product that enhances the activation of heterotrimeric G proteins, which is associated with the occurrence of the splice variant Gβ3 s that could play a role in vascular reactivity and hyperproliferation of smooth muscle cells, that makes such proteins attractive candidate gene products for suscept...
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ژورنال
عنوان ژورنال: Molecular Biology Reports
سال: 2012
ISSN: 0301-4851,1573-4978
DOI: 10.1007/s11033-012-1762-1